April 25, 2014

Summer 2010 Thematic Program on the Mathematics of Drug Resistance in Infectious Diseases

July 19-30
Theme Weeks on Mathematical Immunology

Headed by:
Luis Barreto (Sanofi Pasteur)
Jane Heffernan
Catherine A.A. Beauchemin (Ryerson)

Partners: Sanofi Pasteur, Ontario Agency of Health Protection and Promotion

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Outline of the Program

First week:
Short introductory course (3-4 hours);
4-day workshop on mathematics;
1 day workshop on applications 1 and 2

Second week:
Research Time (4-5 resident faculty);
Friday Colloquium

Schedule (talk titles and abstracts)

Monday July 19
9:30-10:30 am Bhargavi Duvvuri (York University) & Beni Sahai (Cadham Provincial Laboratory & University of Winnipeg)
Short Course: Immunology
10:30-11:00 Break
11:00-12:00 Jane Heffernan (York University)
Short Course: Intro to in-host modelling
12:00-1:15 pm Lunch
1:15-1:30 Welcome and Introduction
Fields Director Ed Bierstone & Workshop Organizers
1:30-2:30 Avidan Neumann (Bar-Ilan University)
Viral Dynamics Modeling - from theory to clinical implications
2:30-3:00 Robert Smith? (University of Ottawa)
Modelling mutation to a cytotoxic T-lymphocyte HIV vaccine
3:00-3:30 Break
3:30-4:00 Lindi Wahl (University of Western Ontario)
Understanding drug resistance in evolving populations of fungus: theory and experiment
4:00-4:30 Shingo Iwami (Japan Science and Technology Agency (JST))
Estimate of viral productivity and infectivity in vitro
4:30-5:30 Reception - cash bar
Fields Atrium
Tuesday July 20
9:30-10:30 am Catherine Beauchemin (Ryerson University)
In-host influenza
10:30-11:00 Break
11:00-12:00 Andreas Handel (University of Georgia)
How sticky should a virus be? The impact of attachment and detachment rates on virus fitness using influenza as an example
12:00-01:30 pm Lunch
1:30-2:00 Venkata Duvvuri (York University)
Highly conserved cross-reactive CD4+ T-cell Hemagglutinin epitopes of seasonal and the 2009 pandemic influenza viruses and their role in the infection dynamics
2:00-2:30 Ben Holder (Ryerson University)
Non-exponential delays in the influenza infection cycle: evidence from in vitro experiments
2:30-3:00 Hana Dobrovolny (Ryerson University)
Neuraminidase inhibitor treatment of seasonal and severe influenza
3:00-3:30 Break
3:30-4:00 Seyed Moghadas (University of Winnipeg)
Within-Host Dynamics of Influenza Drug-Resistance
4:00-4:30 Murray Alexander (National Research Council Canada)
Control of influenza A virus infection by varying death rates of infected cells: Analysis of a spatial model
Wednesday July 21
9:30-10:00 am Stanca Ciupe (University of Louisiana at Lafayette)
Modeling antibody responses during viral infections
10:00-10:30 Elissa Schwartz (Washington State University)
10:30-11:00 Break
11:00-11:30 Mike Gilchrist (University of Tennessee)
Nested Models of Disease Evolution and Its Implications for Understanding Drug Resistance
11:30-12:00 Raluca Eftemie (McMaster University)
Mathematical modeling of cancer immunotherapies: the anti-tumor effect of immune cells versus the anti-tumor effect of oncolytic viruses
  Afternoon off
Thursday July 22
9:30-10:00 am Naveen Vaidya (Los Alamos National Laboratory)
Immunologic Benefits of Enfuvirtide despite Virologic Failure due to the Emergence of Resistance
10:00-10:30 Jessica Conway (University of British Columbia)
Branching process model of viral load and viral blips in individuals on treatment for HIV
10:30-11:00 Break
11:00-11:30 Redouane Qesmi (York University)
HIV Infection Through Breastfeeding Model with Threshold Delay
11:30-12:00 Jonathan Forde (Hobart and William Smith Colleges)
Modeling Hepatitis Delta Infection
12:00-1:30 pm Lunch
1:30-2:00 Tim Reluga (Pennsylvania State University)
A Homeostasis Hypothesis for Hepatitis C Treatment Dynamics
2:00-2:30 Jane Heffernan (York University)
Backward bifurcation in a HBV/HCV model
2:30-3:00 Break
3:00-3:30 Neal Madras (York University)
Stochastic Modeling of Pathogen Mutation and CTL Escape
3:30-4:00 Shinji Nakaoka (University of Tokyo)
A mathematical model for cell division, death and differentiation of CD4 positive T cells
Friday July 23
9:30-10:00 am Sylvia van den Hurk (University of Saskatchewan)
The role of Th1/Th2 polarization in RESPIRATORY SYNCYTIAL VIRUS disease and vaccination
10:00-10:30 Abdolamir Landi
Maturation of Dendritic Cells: Potentials for Mathematical Modelling
10:30-11:00 Break
11:00-11:30 Vahid Anvari (York University)
The Artificial Immune Systems Algorithm Inspired by Dendritic Cells
11:30-12:00 Beni Sahai (Cadham Provincial Laboratory & University of Winnipeg)
Principles of Immunological Control of Antiviral Drug Resistance
12:00-1:30 pm Lunch
1:30-2:00 Natasha Crowcroft (Ontario Agency for Health Protection and Promotion)
2:00-2:30 Shelley Deeks (Ontario Agency for Health Protection and Promotion)
2:30-3:00 Break
3:00-3:30 Discussion
Tuesday July 27 - NOTE LOCATION: 3rd Floor Stewart Library
1:30 - 2:00 pm Troy Day (Queen's University)
2:00 - 3:00 Odo Diekmann (Utrecht University)
The interplay of within-host immunology and population level transmission
Wednesday July 28
  Group Trip

For those who attend more than two blocks of activities, see the List of Confrmed Participants of the Thematic Program.

Confirmed Participants

Full Name University/Affiliation
Alexander, Helen Queen's University
Alexander, Murray National Research Council Canada
Andrews, Rob (no affiliation)
Anvari, Vahid York University
Arino, Julien University of Manitoba
Barreto, Luis Sanofi Pasteur
Barrett, Lisa University of Toronto
Beauchemin, Catherine Ryerson University
Bhattacharyya, Samit University of Guelph
Blumberg, Seth NIH Fogarty/ UCLA
Bowman, Christopher National Research Council, Institute for Biodiagnostics
Chan, Christina University of Toronto
Ciupe, Stanca University of Louisiana at Lafayette
Coleman, B.L. Mount Sinai Hospital
Collinson, Shannon York University
Conway, Jessica University of British Columbia
Crowcroft, Natasha Ontario Agency for Health Protection and Promotion
Dai, Liman University of Western Ontario
Day, Troy Queen's University
Deeks, Shelley Ontario Agency for Health Protection and Promotion
Diekmann, Odo Utrecht University
Dobrovolny, Hana Ryerson University
Du, Yimin York University
Dutta, Tripti York University
Duvvuri, Bhargavi York University
Duvvuri, Venkata York University
Eftimie, Raluca McMaster University
Fan, Guihong York University
Fisman, David The Hospital for Sick Children
Forde, Jonathan Hobart and William Smith Colleges
Ghosh, Suma York University
Gilchrist, Michael University of Tennessee
Gourley, Stephen University of Surrey
Guo, Hongbin York University
Guo, Shangjiang Hunan University
Halevy, Itamar  
Handel, Andreas University of Georgia
Hauck, Tanya School of Public Health
Heffernan, Jane York University
Holder, Ben Ryerson University
Hurford, Amy Queen's University
Iwami, Shingo Japan Science and Technology Agency (JST)
Jacobs, Naamah York University
Labibi, Batool University of Toronto
Landi, Abdolamir University of Saskatchewan
Li, Jia University of Alabama in Huntsville
Li, Jing University of Ottawa
Liu, Rongsong University of Wyoming
Liu, Shengqiang Harbin Institute of Technology
Lou, Yijun York University
Lui, Roger Worcester Polytechnic Institute
Madras, Neal York University
Moghadas, Seyed University of Winnipeg
Murall, Carmen Lía University of Guelph
Nakaoka, Shinji University of Tokyo
Neumann, Avidan Bar-Ilan University
Ngo, Thanh Ryerson University
Pahlevani, Faranak Stevens Institute of Technology
Pawelek, Kasia Oakland University
Portet, Stéphanie University of Manitoba
Qesmi, Redouane York University
Reluga, Timothy Pennsylvania State University
Ruan, Shigui University of Miami
Rudnick, Wallis Mount Sinai Hospital
Sahai, Beni Cadham Provincial Laboratory & University of Winnipeg
Saini, Jasmik University of Toronto
Schwartz, Elissa Washington State University
Smith?, Robert University of Ottawa
Soho, Edme Arizona State University
Sun, Chengjun University of Manitoba
Taylor, Edward The Ohio State University
Toro Zapata, Hernán Dario University of Quindio
Tuite, Ashleigh University of Toronto
Upadhyayula, Suryanarayana Murty Indian Institute of Chemical Technology, CSIR
Vaidya, Naveen Los Alamos National Laboratory
van den Hurk, Sylvia University of Saskatchewan
Wahl, Lindi University of Western Ontario
Wan, Hui York University
Wang, Qian York University
Wang, Xiaoxia Case Western Reserve University
Wang, Yan University of British Columbia
Wang, Ying The Ohio State University
Wong, Eva University of Toronto
Wu, Jianhong York University
Xiao, Yanyu University of Western Ontario
Zhou, Yinggao York University
Zhu, Huaiping York University
Zou, Shaofen York University
Zou, Xingfu University of Western Ontario


Program Visitors

All scientific events are open to the mathematical sciences community. Visitors who are interested in office space or funding are requested to apply by filling out the application form. Additional support is available (pending NSF funding) to support junior US visitors to this program. Fields scientific programs are devoted to research in the mathematical sciences, and enhanced graduate and post-doctoral training opportunities. Part of the mandate of the Institute is to broaden and enlarge the community, and to encourage the participation of women and members of visible minority groups in our scientific programs.

For additional information contact thematic(at)

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