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Fri.
May 10, 2013 at 1:00 pm Chancellor's Professor and ChairIvan
Soltesz, University of California (Irvine) Organization and Control of Hippocampal Chronocircuits
Location: Auditorium, Toronto Western Hospital
Sponsors | Toronto
Western Research Institute (TWRI), UHN, Collaborative
Program in Neuroscience (CPIN), and Center for Mathematical
Medicine (CMM- Fields)
PAST TALKS
Friday,
April 26 (FieldsLive
video) Dr. Matthew Doyle, Cellular Mechanobiology Lab,
University of Toronto,
Location: Fields Institute, Room 210
Calculation
of the mechanical properties of trilayer porcine aortic
valve leaflets using an experimental, computational, and
analytical approach The mechanical properties of a material relate
the applied force to the resulting deformation. In this
study, we are interested in calculating the microscale
mechanical properties of each of the three layers of porcine
aortic valve leaflets. These properties are important
to cell biologists looking to understand the microenvironment
surrounding valve cells and how changes to this environment
promote or inhibit cell differentiation. In this talk,
I will describe the experimental, computational, and analytical
approaches used to calculate these mechanical properties.
Experimentally, we indented excised leaflets using a purpose-built
microindenter to obtain force-indentation depth data.
Computationally, we performed inverse finite element simulations
in conjunction with non-linear optimization to determine
the parameter values for the material models representing
each of the layers. Analytically, we developed mathematical
models to address the ill-posedness of the inverse finite
element problem by providing initial estimates of the
material parameter values for each layer to use as initial
conditions in the simulations to ensure the solution converges
to the correct values.
Thurs. March 28, 2013 at 10:00 a.m.
Location:
Fields Institute, Stewart Library
Dr. Jason Levy, University of Ottawa
Ergodic Rate Analysis: extracting
dynamics and regulation fromimages of fixed cells
Biologists have long been concerned about what constrains
variation in cell size, but progress in this field has been
slow and stymied by experimental limitations. We describe
a new mathematical method, ergodic rate analysis (ERA),
that uses single-cell measurements of fixed steady-state
populations to accurately infer the rate of cell growth
and full time trajectories of any feature that can be labelled
in fixed cells, for example levels of phospho-proteins or
total cellular mass. Using ERA we find evidence for a size
discriminatory process at the G1/S transition that acts
to decrease cell-to-cell size variation. This work is joint
with colleagues at Harvard Medical School and has recently
(Feb. 28, 2013) appeared in Nature.
Fri. Jan. 25 at 10:00 a.m.
Dr. Masami Tatsuno (Lethbridge University) Place: The Fields Institute, Centre for Mathematical
Medicine, Toronto
Experimental
findings and data analyses of memory reactivation
In a resting period during a task or in the subsequent
sleep following a task, many neurons in various parts
of the brain become reactivated, often with firing patterns
similar to those that occurred during a task. This reactivation
is thought to play an important role in the process of
memory consolidation. Firstly, in this talk, I will summarize
the experimental findings of memory reactivation in early
studies (1989-2000). The analysis of this time period
relies mainly on first-order and second-order statistics.
Secondly, I will describe the further developments of
research in the second decade (2001-2010). We will see
that the analyses have expanded to include higher-order
statistics. Thirdly, I will describe the present status
and challenges of memory reactivation research, including
our recent attempt in data analysis. I hope the talk will
stimulate the audience's interest in neuroscience.
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