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March 29-31, 2012
Workshop on Mathematical Oncology IV: Integrative Cancer Biology,
to be hosted at the
Fields Institute

Organizing Committee:
M. Kohandel
University of Waterloo & CMM
P. Maini
University of Oxford & CMB
V. Quaranta
Vanderbilt University & VICBC
S. Sivaloganathan
University of Waterloo & CMM
Fee $50, students &PDF $25, waived for invited speakers
on-site March 29

Cancer is a dynamical disease characterized by interactions at multiple scales ranging from the genetic level, through the cellular level to its eventual manifestation at the tissue level. The mantras, in recent years, of "molecular medicine" and "personalized medicine" have led to a gradual realization that novel integrative models (that couple information flow across multiple scales) are central for reaching a deeper understanding of the pathophysiology of various cancers and their effective treatment. This appears to be the key challenge lying at the frontiers of the interdisciplinary field of mathematical oncology.

This workshop brings together an international group of leading clinical, mathematical and basic scientists working at the cutting edge of cancer research. The topics covered will span a broad spectrum of problems of current interest in cancer biology and clinical oncology.

Meeting Program: Audio and Slides available here

Thursday, March 29
8:30-8:55 Morning Coffee and Onsite Registration
8:55-9:00 Welcome: V. Quaranta, S. Sivaloganathan
9:00-9:45 John Dick (Ontario Cancer Institute)
Towards unification of genetic and hierarchy models of tumor heterogeneity
9:50-10:30 Jan Liphardt (UC Berkeley)
10:30-10:45 Coffee Break
10:45-11:30 Richard Hill (Ontario Cancer Institute & UHN)
Cancer Metastases
11:40-12:20 Robert Gatenby (H. Lee Moffitt Cancer Center, Florida)
Evolutionary dynamics in cancer therapy
12:20-2:10 Lunch Break
2:10-2:50 Bradly Wouters (OCI/Princess Margaret Hospital, UHN, UofT, OICR)
Biological responses to tumor hypoxia and their potential as therapeutic targets
2:55-3:35 Sheila Singh (Stem Cell & Cancer Research Institute, McMaster)
Medulloblastoma stem cells: where development and cancer cross pathways
3:40-4:00 Coffee Break
4:05-4:45 Natalia Komarova (UC, Irvine)
Cellular cooperation as a pathway to cancer
5:00-6:00 Reception
Friday, March 30
8:30-9:00 Morning Coffee
9:00-9:40 Vito Quaranta (Vanderbilt University & VICBC)
Cancer cell population dynamics of drug response derived from single-cell data
9:45-10:25 Edwin Wang (National Research Council, Canada & McGill U)
Personalized cancer healthcare: A systems biology approach
10:30-10:45 Coffee Break
10:45-11:25 Mike Milosevic (Princess Margaret Hospital & UHN)
Imaging Biology and Treatment Response in Cervical Cancer
11:30-12:10 Jasmine Foo (University of Minnesota)
Modeling tumor heterogeneity and drug resistance
12:15-2:10 Lunch Break
2:10-2:50 Sendurai Mani (Anderson Cancer Center)
EMT and Stem Cells in Cancer Progression
2:55-3:35 Mohammad Kohandel (University of Waterloo)
Quantitative approaches to cancer stem cell hypothesis
3:35-3:55 Coffee Break
3:55-4:35 Harsh Jain (Ohio State University)
Optimizing ovarian cancer treatment with Mathematics: Carboplatin + Anti-Bcl-2/xL combination therapy
Saturday, March 31
8:30-9:00 Morning Coffee
9:00-9:40 Chris McFarland (Harvard University/Program in biophysics)
The impact of deleterious passenger mutations on cancer progression
9:45-10:25 Kathleen Wilkie (CCSB, St. Elizabeth's Med. Cent.,Tufts)
A Mathematical Model of Immune Modulation of Tumor Growth
10:30-10:50 Coffee Break
10:50-11:30 Colin Phipps (University of Waterloo)
Mathematical model for angiogenic behaviour in solid tumours
11:35-11:40 Closing Remarks (S. Sivaloganathan)
11:45-12:30 Coffee Break & End of Meeting

Confirmed participants as of March 26, 2012

Full Name University/Affiliation
Abdi Dezfooli, Zhamak University of Toronto
Burazin, Andrijana University of Waterloo
Chan-Seng-Yue, Michelle Ontario Institute for Cancer Research
Chu, Kenneth Ontario Institute for Cancer Research
Clarke, Geoff University of Toronto
Dick, John Ontario Cancer Institute
Fasano, Antonio UniversitÓ degli Studi di Firenze
Foo, Jasmine University of Minnesota
Gatenby, Robert H. Lee Moffitt Cancer Center
Hill, Richard Princess Margaret Hospital
Jain, Harsh Vardhan Mathematical Biosciences Institute
Karabekmez, Remziye University of Waterloo
Kohandel, Mohammad University of Waterloo
Komarova, Natalia University of California, Irvine
Liphardt, Jan University of California, Berkeley
Mak, Denise Ontario Institute for Cancer Research
Manem, Venkata University of Waterloo
Mani, Sendurai M. D. Anderson Cancer Center
McFarland, Chris Massachusetts Institute of Technology
Milosevic, Michael University of Toronto, Princess Margaret Hospital
Murley, Jonathan University of Waterloo
Ng, Stanley University of Toronto
Phipps, Colin University of Waterloo
Qazi, Maleeha McMaster University
Qiao, Wendy University of Toronto
Quaranta, Vito Vanderbilt University
Sarangi, Sasmit Brigham And Women's Hospital
Sethi, Sukhmani McMaster University
Singh, Sheila McMaster University
Sivaloganathan, Sivabal University of Waterloo
Soos, Boglarka University of Waterloo
Wang, Edwin National Research Council Canada
Wilkie, Kathleen Tufts University School of Medicine
Wouters, Bradly Princess Margaret Hospital
Yan, Rui Ontario Institute for Cancer Research
Zhou, Joseph Xu University of Calgary
Zia, Amin Ontario Institute for Cancer Research
Jadallah, Hala
Saldana, Rafael Ateneo de Manila University

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