Location: Fields Institute , 222 College Street, Toronto

October 9, 2009- 3:30 p.m.
Naveen K. Vaidya
Theoretical Biology and Biophysics Group, Los Alamos National Laboratory
Audio of the Talk

HIV Treatment: From Primary Phase to Chronic Phase

In the first part of this talk, I will discuss HIV treatment models during primary
infection, which include a recently observed time-dependent virus infectiousness. I will show how the time-dependent infectiousness affects optimal controls of therapy. In the second part, I will focus on HIV treatment during the chronic phase of infection, in which emergence of drug resistance is a major issue. I will discuss viral dynamic properties of HIV during partial interruption and subsequent administration of a drug. Results show that the dominance of the drug-sensitive or drug-resistant strains is de- termined by fitness cost of the drug-resistant virus while the plasma viral load level is determined by target cell availability. Even though the drug seems ineffective in sup- pressing plasma viral load due to emergence of drug-resistant viruses, re-administration of the drug following a partial interruption may provide a sustained CD4+ T cell benefit.

Joint Work With: Libin Rong, Ruy M. Ribeiro & Alan S. Perelson, Los Alamos Na-
tional Laboratory, Los Alamos, NM, USA

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