Location: Fields Institute
, 222 College Street, Toronto
May 15, 2009- 3:30 p.m.
Alan Perelson Theoretical Biology & Biophysics Group,
Los Alamos National Laboratory
The Dynamics of
Virus Infection and Treatment
I will present the fundamental
principles of a new field called viral dynamics.
I will illustrate those principles using examples
from human immunodeficiency virus (HIV) and hepatitis
C virus (HCV) infection. I will show how, using
simple dynamic models combined with experimental
data, one is able to uncover basic features of the
biology of viral infection and assess the efficacy
of different treatment protocols. If time permits,
I will present both stochastic and deterministic
models. The talk will illustrate how using kinetic
information has changed the way clinical trials
of new antiviral agents are performed as well as
how it has influenced the strategies by which anti-viral
therapies are administered.