Lindi Wahl, University of Western Ontario Recurrent Viral Infection: Why Recurrence Doesn't
Need a Trigger
In chronic viral infection,
low levels of viral replication are maintained over
long periods, but may be punctuated by brief bursts
of high viral production and release. We demonstrate
that a model which incorporates the contributions
of both cytotoxic T lymphocytes (the killer cells
of the immune system) and antibodies exhibits long
periods of quiescence followed by brief bursts of
viral production. This suggests that for recurrent
viral infections, no special mechanism or exogenous
trigger is necessary to provoke an episode of reactivation.
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