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July 27, 2007
Workshop on Brain Biomechanics: Mathematical Modelling of Hydrocephalus and Syringomyelia

The last two decades have witnessed an explosion in the interactions and synergy between the mathematical and biomedical sciences. The development of an accurate mathematical model suitable for the simulation of the mechanical behaviour of the human brain under different loading scenarios will be the touchstone that may well lead to significant advances in the clinical neurosciences. In particular, it would lay the groundwork for model predictions of the damage sustained by the brain in a variety of loading conditions from hydrocephalus and syringomyelia to brain trauma and would thus provide aid in treatment decisions. However, such an endeavour clearly requires a multidisciplinary approach. This workshop will focus on models of hydrocephalus and syringomyelia and bring together leading clinician/scientists, experimentalists and theoreticians currently engaged in this field. The aims of the workshop are to review the state of the field, update participants on current progress and chart future directions.

Talks will be 20 minutes in length with an additional 5 minutes for questions/short

Invited Participants

N. Alperin (University of Illinois at Chicago)
N. Chrisochoides (William & Mary)
B. Cohen (Rensselaer Polytechnic)
C. Drapaca (Waterloo)
M. Egnor (Stoney Brook)
R. Ehman (Mayo)
M. Johnston (Toronto)
M. Kohandel (Waterloo)
D. Levine (New York)
J. Madsen (Boston)

S. Margulies (Pennsylvania)
A. Marmarou (Virginia)
P. McAllister (Wayne State)
R. Penn (Chicago)
H. Rekate (Arizona)
C.Stewart (Arizona)
G. Tenti (Waterloo)
M. Wagshul (Stoney Brook)
M. Walker (Utah)
K. Wilkie (Waterloo)



Registration fee for this event is $50 CDN, $25 for students and PDF's, fee is waived for invited participants. Registration fee will cover on-site refreshments.

Particpants List

Fullname University Name
Alperin, Noam University of Illinois at Chicago
Batay, Judy  
Chrisochoides, Nikos P. College of William and Mary
Cohen, Benjamin Rensselaer Polytechnic Institute
Drake, James M. The Hospital for Sick Children
Drapaca, Corina University of Waterloo
Egnor, Michael Stony Brook University
Ehman, Richard L. Mayo Clinic
Gunawan, Rudy University of Waterloo
Johnston, Miles University of Toronto
Neuroscience Research Program
Kazina, Colin University of Manitoba
Kohandel, Mohammad University of Waterloo
Levine, David NYU Medical Center
Madsen, Joseph R. Children's Hospital, Harvard Medical School
Margulies, Susan University of Pennsylvania
Marmarou, Anthony Virginia Commonwealth University
McAllister, James P. Wayne State University School of Medicine
Park, Eun-Hyoung Children's Hospital Boston, Harvard Medical School
Penn, Richard University of Chicago
Powathil, Gibin University of Waterloo
Rekate, Harold L. University of Arizona
Rohlf, Katrin Ryerson University
Sivaloganathan, Sivabal University of Waterloo
Speziale, Sean University of Waterloo
Stewart, Curt The BrainChild Foundation
Stinchcombe, Adam University of Waterloo
Su, Wanhua University of Waterloo
Tang, Herbert University of Waterloo
Tenti, Giuseppe University of Waterloo
Turner, Colin University of Waterloo
Wagshul, Mark SUNY Stony Brook
Walker, Marion L. University of Utah
Wang, Yanwei University of Waterloo
Wilkie, Kathleen University of Waterloo
Zamir, Mair Univesity of Western Ontario


Thursday, July 26, 2007
7:00 p.m. Early Registration and Reception
Friday July 27, 2007
7:30am - 8am Continental Breakfast
7:55am - 8am Welcome - Jim Drake/Siv Sivaloganathan
8:00am - 8:20am M. Wagshul, SUNY Stony Brook
Intracranial flow and pressure: What can we measure?
8:25am - 8:45am R. Penn, University of Chicago
Physics of Hydrocephalus
8:50am - 9:10am R. Ehman, Mayo Clinic
Magnetic Resonance Elastography by Direct MR Visualization of Propagating Shear Waves
9:15am - 9:35am B. Cohen, Rensselaer Polytechnic Institute
A Mechanics-Based Framework Leading to the Diagnosis and Treatment of Hydrocephalus
9:40am - 10:00am N. Alperin, University of Illinois at Chicago
"MRI based noninvasive measurement of intracranial compliance: direct vs. modeling based approach."
10:05am - 10:25am D. Levine, NYU Medical Center
Intracranial Pressure in Hydrocephalus
10:25am - 10:40am Coffee/Tea Break
10:40am - 11:00am M. Egnor, Stony Brook University
Modeling of Phase, Amplitude and Transfer Function of Carotid Arterial Pulse Pressure and Intracranial Pulse Pressure in Dogs
11:00am - 11:20am K. Wilkie, University of Waterloo
A Pulsatile Cerebrospinal Fluid Model for Hydrocephalus
11:20am - 11:40am H. Rekate, University of Arizona
All Forms Of Hydrocephalus Can Be Explained By Derangements of Bulk Flow 30 Years of Research Driven By A Bulk Flow Model

11:50am - 12:40pm Panel Discussion (Theoretical Aspects)
M. Egnor, R. Penn, D. Levine, N. Alperin
12:40pm - 2:00pm Lunch Break
2:00pm - 2:20pm D. Levine, NYU Medical Center
The Syrinx as a Biological Pothole
2:25pm - 2:45pm P. McAllister, Wayne State University School of Medicine
Probable Cellular Influences on the Biomechanical Properties of the Brain: The "Sponge" Changes during Hydrocephalus
2:50pm - 3:10pm M. Johnston, University of Toronto
In search of mechanisms to explain ventricular expansion in communicating hydrocephalus
3:15pm - 3:35pm C. Drapaca, University of Waterloo
Application of Potential Theory to MR Elastography
3:40pm - 4:00pm S. Margulies, University of Pennsylvania
Mechanical Properties of Brain Tissue
4:00pm - 4:15pm Coffee/Tea Break
4:20pm - 4:40pm A. Marmarou, Virginia Commonwealth University
4:45pm - 5:05pm J. Madsen, Children's Hospital, Harvard Medical School
Intracranial pulsations and their characteristics in hydrocephalus: inferences from the frequency domain
5:10pm - 5:30pm N. Chrisochoides, College of William and Mary
Near Real-Time Non-Rigid Registration of pre- and intra-operative MRI for Image Guided Neurosurgery
5:35pm - 6:30pm Panel Discussion (Experimental Aspects)
P. McAllister, M. Johnston, S. Margulies, J. Madsen
6:30pm - 6:35pm Closing Remarks Jim/Siv

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